Allergen Screening for Personal Care Products

Within the scope of cosmetic safety assessment, it is aimed to detect and determine the amounts of substances defined as common fragrance allergens with the fragrance allergen screening test. Fragrance ingredients used as perfume ingredients can cause allergic contact dermatitis, pigmented cosmetic dermatitis, and photosensitivity. Fragrance allergen screening test is important in determining allergen fragrance substances that should be specified in the label information in terms of consumer health.

Defines the requirement that any of the 26 substances listed in regulation 1223/2009 in Europe be included in the label ingredient list. According to the regulation, if perfume allergens are higher than 0.01% in cosmetic products such as soap, shampoo and shower gel, it must be stated on the label. If the product in question is a permanent cosmetic product such as a skin cream, it should be stated on the label if it is higher than 0.001%.

The odor allergens listed within the scope of the regulation are as follows:

• Amyl cinnamal (CAS No 122-40-7)
• Benzyl alcohol (CAS No 100-51-6)
• Cinnamyl alcohol (CAS No 104-54-1)
• Citral (CAS No 5392-40-5)
• Eugenol (CAS No 97-53-0)
• Hydroxy-citronellal (CAS No 107-75-5)
• Isoeugenol (CAS No 97-54-1)
• Amylcin-namyl alcohol (CAS No 101-85-9)
• Benzyl salicylate (CAS No 118-58-1)
• Cinnamal (CAS No 104-55-2)
• Coumarin (CAS No 91-64-5)
• Geraniol (CAS No 106-24-1)
• Hydroxy-methylpentylcyclohexenecarboxaldehyd (CAS No 31906-04-4)
• Anisyl alcohol (CAS No 105-13-5)
• Benzyl cinnamate (CAS No 103-41-3)
• Farnesol (CAS No 4602-84-0)
• 2-(4-tert-Butylbenzyl) propionald-hyd (CAS No 80-54-6)
• Linalool (CAS No 78-70-6)
• Benzyl benzoate (CAS No 120-51-4)
• Citronellol (CAS No 106-22-9)
• Hexyl cinnam-aldehyd (CAS No 101-86-0)
• d-Limonene (CAS No 5989-27-5)
• Methyl heptin carbonate (CAS No 111-12-6)
• 3-Methyl-4-(2,6,6-tri-methyl-2-cyclohexen-1-yl)-3-buten-2-one (CAS No 127-51-5)
• Oak moss and treemoss extract (CAS No 90028-68-55)
• Treemoss extract (CAS No 90028-67-4)